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KMID : 0376219850220010093
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Chonnam Medical Journal
1985 Volume.22 No. 1 p.93 ~ p.109
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The Fine Structure of the Epithelium in Appendix Vermiformis of the Rat
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Abstract
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In an attempt to correlate the structure of rat appendix with its role in the immunological defense mechanism of the body, electron microscopic studies were made. on the rat appendicular epithelium and the cells of lamina propre. The results obtained were summarized as follows.
The epithelium of rat appendix was simple columnar type, and consisted, basically, of 4 cell types; columnar cells, goblet cells, enteroendocrine cells, and caveolated cells. In addition to these cell types lymphocytes, macrophages, and plasma cells often closely contacting were observed.
Columnar cells were major cell type, and characterized by having the slender microvilli at the luminary surface, and vesicles, mitochondria, Golgi apparatus, and dense bodies in the supranuclear region. In some occasions they contained clusters of apparently intact E. Coli in a large apical vacuole and E. Coli in lying processes within the dense bodies.
Goblet cells were all common type, and granular goblet cells were not observed.
Caveolated cells were a rare cell type and characterized by their wedge shaped outline, long and thick microvilli, and abundant cytoplasmic vacuoles. The cytoplasm and nucleus of caveolated cell was lighter than that of columnar cell.
Enteroendocrine cells contained numerous serectory granules of variable size, shape, and density.
E. Coli, were abundant in the appendicular lumen, and were present in the intracytoplasmic structures of the columnar cells as described.
Lamina propre of the rat appendix contained very ,few lymphoid follicles, however, were populated with abundant lymphocytes, plasma cells, macrophages, eosinophiles, and mast cells among the fibroblasts. Frequently macrophages were in intimate contact with plasma cells or lymphocytes.
In summary, intimate contact of macrophages with plasma cells or lymphocytes observed in the epithelium and the lamina propre supports the fact that there were close macrophage-plasma cell or macrophage-lymphocyte interactions in immune response. And also, E. Coli present in the appendicular lumen and in the columnar cells were considered to be significant in the defense system of the body.
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